上海允兒實(shí)業(yè)有限公司為您提供mi-1061代理。mce 的所有產(chǎn)品僅用作科學(xué)研究,我們不為任何個(gè)人用途提供產(chǎn)品和服務(wù)。
mi-1061
產(chǎn)品活性:mi -1061 是一種有效的,-可生物利用的,化學(xué)穩(wěn)定性的 mdm2 (mdm2-p53 互作) --- (ic50=4.4 nm; ki=0.16 nm)。mi -1061 能有效--- p53,---細(xì)胞凋亡,并具有抗---活性。
研究領(lǐng)域:apoptosis | metabolic enzyme/protease
作用靶點(diǎn):mdm-2/p53 | e1/e2/e3 enzyme | apoptosis
in vitro: mi -1061 achieves ic50=100&250 nm in the sjsa-1&hct-116 p53+/+ cell lines, respectively,&has ic50>10000 nm in the p53 knockout cell line hct-116 p53–/–cell line.
in vivo: mi-1061 is capable of achieving tumor regression in the sjsa-1 xenograft tumor model in mice with oral administration.
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mi-1061產(chǎn)品鏈接:
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